Tag

Physiology
26
Mar

Roles of circadian clocks in cancer pathogenesis and treatment

March 26, 2022
Lee, Y. Roles of circadian clocks in cancer pathogenesis and treatment. Exp Mol Med 53, 1529–1538 (2021). https://doi.org/10.1038/s12276-021-00681-0 Abstract Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h rhythms in cellular and bodily functions across nearly all living species. These internal clock systems enable living organisms to anticipate and respond to daily changes in their environment in...
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26
Mar

Foundations of circadian medicine

March 26, 2022
Citation: Kramer A, Lange T, Spies C, Finger A-M, Berg D, Oster H (2022) Foundations of circadian medicine. PLoS Biol 20(3): e3001567. https://doi.org/10.1371/journal.pbio.3001567 Abstract The circadian clock is an evolutionarily highly conserved endogenous timing program that structures physiology and behavior according to the time of day. Disruption of circadian rhythms is associated with many common pathologies....
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17
Feb

Immune cells that clear away Alzheimer’s disease protein are controlled by circadian rhythms

February 17, 2022
Citation: Clark GT, Yu Y, Urban CA, Fu G, Wang C, Zhang F, et al. (2022) Circadian control of heparan sulfate levels times phagocytosis of amyloid beta aggregates. PLoS Genet 18(2): e1009994. https://doi.org/10.1371/journal.pgen.1009994 http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009994 The findings provide a mechanism that links Alzheimer’s disease with circadian rhythm disruptions Peer-Reviewed Publication PLOS Researchers report that the immune cells...
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25
Sep

Cancer as a homeostatic challenge: the role of the hypothalamus

September 25, 2021
Francis N, Borniger JC. Cancer as a homeostatic challenge: the role of the hypothalamus. Trends Neurosci. 2021 Sep 21:S0166-2236(21)00167-3. doi: 10.1016/j.tins.2021.08.008. Epub ahead of print. PMID: 34561122. Abstract The initiation, progression, and metastatic spread of cancer elicits diverse changes in systemic physiology. In this way, cancer represents a novel homeostatic challenge to the host system....
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01
May

Nighttime Light Hurts Mammalian Physiology: What Diurnal Rodent Models Are Telling Us

May 1, 2021
Mendoza, J. Nighttime Light Hurts Mammalian Physiology: What Diurnal Rodent Models Are Telling Us. Clocks & Sleep 2021, 3, 236-250. https://doi.org/10.3390/clockssleep3020014 Abstract Natural sunlight permits organisms to synchronize their physiology to the external world. However, in current times, natural sunlight has been replaced by artificial light in both day and nighttime. While in the daytime, indoor artificial light...
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18
Sep

Sexual dimorphism in body clocks

September 18, 2020
Science  04 Sep 2020:Vol. 369, Issue 6508, pp. 1164-1165DOI: 10.1126/science.abd4964 Summary Circadian rhythms, or the body clock, confer temporal structure on human behavior and physiology to align homeostatic processes with anticipated changes in the environment. Disruption of these rhythms can influence health and well-being. Chronobiological research has often failed to consider how this temporal organization may...
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13
Oct

The role of the circadian clock system in physiology.

October 13, 2019
Pflugers Arch. 2018 Feb;470(2):227-239. doi: 10.1007/s00424-017-2103-y. Epub 2018 Jan 4. Life on earth is shaped by the 24-h rotation of our planet around its axes. To adapt behavior and physiology to the concurring profound but highly predictable changes, endogenous circadian clocks have evolved that drive 24-h rhythms in invertebrate and vertebrate species. At the molecular level,...
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