Tag

Circadian Disruption
06
Nov

We’re all sensitive to light at night, but some are much, much more sensitive than others

November 6, 2019
by Elise McGlashan, PhD & Parisa Vidafar, PhD on November 5th 2019 in Clocks in the Spotlight Humans evolved in an environment with only very bright (sun) or very dim (moon or fire) sources of light. Today, artificial lighting enables us to spend hours per day at intermediate light levels. Our recent study shows that the response of the...
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06
Nov

High sensitivity and interindividual variability in the response of the human circadian system to evening light

November 6, 2019
PNAS June 11, 2019 116 (24) 12019-12024; first published May 28, 2019 https://doi.org/10.1073/pnas.1901824116 Significance: Electric lighting has fundamentally altered how the human circadian clock synchronizes to the day/night cycle. Exposure to light after dusk is pervasive in the modern world. We examined group-level sensitivity of the circadian system to evening light and the degree to which sensitivity varies between individuals. We...
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20
Oct

Artificial light-at-night – a novel lifestyle risk factor for metabolic disorder and cancer morbidity

October 20, 2019
Abstract Both obesity and breast cancer are already recognized worldwide as the most common syndromes in our modern society. Currently, there is accumulating evidence from epidemiological and experimental studies suggesting that these syndromes are closely associated with circadian disruption. It has been suggested that melatonin (MLT) and the circadian clock genes both play an important...
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17
Oct

Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila

October 17, 2019
Published: 17 October 2019  Abstract: Light is necessary for life, but prolonged exposure to artificial light is a matter of increasing health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs), which can interfere with normal sleep cycles. The LED technologies are relatively new; therefore, the long-term...
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10
Oct

Influence of the modern light environment on mood.

October 10, 2019
Mol Psychiatry. 2013 Jul;18(7):751-7. doi: 10.1038/mp.2013.70. Epub 2013 May 28. Abstract Humans and other organisms have adapted to a consistent and predictable 24-h solar cycle, but over the past ~130 years the widespread adoption of electric light has transformed our environment. Instead of aligning behavioral and physiological processes to the natural solar cycle, individuals respond to...
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27
Aug

BRCA1 and BRCA2 Gene Expression: Diurnal Variability and Influence of Shift Work

August 27, 2019
Cancers 2019, 11(8), 1146; https://doi.org/10.3390/cancers11081146 Received: 10 July 2019 / Revised: 5 August 2019 / Accepted: 7 August 2019 / Published: 9 August 2019 (This article belongs to the Special Issue 3rd Etnean Occupational Medicine Workshop—Breast Cancer and Work) Abstract BRCA1 and BRCA2 genes are involved in DNA double-strand break repair and related to breast cancer. Shift work is associated with biological clock...
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05
Jul

IARC Monographs evaluation of the carcinogenicity of night shift work

July 5, 2019
5 July 2019 The results of the recent IARC Monographs evaluation of the carcinogenicity of night shift work have now been published in The Lancet Oncology. This summary article presents the conclusions of the IARC Monographs Meeting 124. Shift work involving circadian disruption was previously evaluated by the IARC Monographs, in 2007. In this updated evaluation, the Working Group chose the...
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15
May

French Agency ANSES Press release – LED: recommendations to limit exposure to blue light

May 15, 2019
Source: https://www.anses.fr/fr/content/led-les-recommandations-de-l%E2%80%99anses-pour-limiter-l%E2%80%99exposition-%C3%A0-la-lumi%C3%A8re-bleue While the use of LEDs is becoming more widespread for lighting and LED objects are on the increase, ANSES published the update of its 2010 expertise on the health effects of LEDs in light of the new scientific knowledge available. The Agency confirms the toxicity of blue light on the retina and highlights effects...
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04
Mar

Disruption of central and peripheral circadian clocks in police officers working at night

March 4, 2019
Published Online:27 Feb 2019 https://doi.org/10.1096/fj.201801889R Abstract Working atypical schedules leads to temporal misalignments between a worker’s rest-activity cycle and their endogenous circadian system. Several studies have reported disturbed centrally controlled rhythms, but little is known on shift workers’ peripheral clocks. Here, we assessed central clock markers, urinary 6-sulfatoxymelatonin and salivary cortisol, and clock gene expression in...
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19
Jan

Timing of light exposure affects mood and brain circuits

January 19, 2019
Abstract Transl Psychiatry. 2017 Jan; 7(1): e1017. Published online 2017 Jan 31. doi: 10.1038/tp.2016.262 Temporal organization of physiology is critical for human health. In the past, humans experienced predictable periods of daily light and dark driven by the solar day, which allowed for entrainment of intrinsic circadian rhythms to the environmental light–dark cycles. Since the adoption...
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