Tag

Circadian Clock
21
Jan

Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells

January 21, 2021
Ch, R., Rey, G., Ray, S. et al. Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells. Nat Commun 12, 377 (2021). https://doi.org/10.1038/s41467-020-20479-4 Abstract Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs),...
Read More
19
Dec

Protein involved in removing Alzheimer’s buildup linked to circadian rhythm

December 19, 2020
Source: https://medicine.wustl.edu/news/protein-involved-in-removing-alzheimers-buildup-linked-to-circadian-rhythm/ Brain protein helps explain link between circadian rhythm, Alzheimer’s disease by Tamara Bhandari•December 16, 2020 Fractured sleep, daytime sleepiness and other signs of disturbance in one’s circadian rhythm are common complaints of people with Alzheimer’s disease, and the problems only get worse as the disease progresses. But the reason for the link between Alzheimer’s...
Read More
10
Dec

Chronic circadian shift leads to adipose tissue inflammation and fibrosis

December 10, 2020
Xiong X, Lin Y, Lee J, Paul A, Yechoor V, Figuero M, Ma K. Chronic circadian shift leads to adipose tissue inflammation and fibrosis. Mol Cell Endocrinol. 2020 Dec 4:111110. doi: 10.1016/j.mce.2020.111110. Epub ahead of print. PMID: 33285245. Abstract The circadian clock exerts temporal coordination of metabolic pathways. Clock disruption is intimately linked with the...
Read More
06
Nov

We’re all sensitive to light at night, but some are much, much more sensitive than others

November 6, 2019
by Elise McGlashan, PhD & Parisa Vidafar, PhD on November 5th 2019 in Clocks in the Spotlight Humans evolved in an environment with only very bright (sun) or very dim (moon or fire) sources of light. Today, artificial lighting enables us to spend hours per day at intermediate light levels. Our recent study shows that the response of the...
Read More
06
Nov

High sensitivity and interindividual variability in the response of the human circadian system to evening light

November 6, 2019
PNAS June 11, 2019 116 (24) 12019-12024; first published May 28, 2019 https://doi.org/10.1073/pnas.1901824116 Significance: Electric lighting has fundamentally altered how the human circadian clock synchronizes to the day/night cycle. Exposure to light after dusk is pervasive in the modern world. We examined group-level sensitivity of the circadian system to evening light and the degree to which sensitivity varies between individuals. We...
Read More
13
Oct

The role of the circadian clock system in physiology.

October 13, 2019
Pflugers Arch. 2018 Feb;470(2):227-239. doi: 10.1007/s00424-017-2103-y. Epub 2018 Jan 4. Life on earth is shaped by the 24-h rotation of our planet around its axes. To adapt behavior and physiology to the concurring profound but highly predictable changes, endogenous circadian clocks have evolved that drive 24-h rhythms in invertebrate and vertebrate species. At the molecular level,...
Read More
03
Sep

Nobel Lecture: Michael Rosbash, Nobel Prize in Physiology or Medicine, 2017

September 3, 2019
The Circadian Clock, Transcriptional Feedback and the Regulation of Gene Expression. The 2017 Nobel Lectures in Physiology or Medicine were held on 7 December at the Aula Medica, Karolinska Institutet.
Read More
12
Jun

Magnetocarcinogenesis: is there a mechanism for carcinogenic effects of weak magnetic fields?

June 12, 2018
Juutilainen J, Herrala M, Luukkonen J, Naarala J, Hore PJ. Magnetocarcinogenesis: is there a mechanism for carcinogenic effects of weak magnetic fields? Proc Biol Sci. 2018 May 30;285(1879):20180590. doi: 10.1098/rspb.2018.0590. PMID: 29794049; PMCID: PMC5998098. Abstract Extremely low-frequency (ELF) magnetic fields have been classified as possibly carcinogenic, mainly based on rather consistent epidemiological findings suggesting a...
Read More
1 2