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Cancer
Photo by Q.U.I on Unsplash “There is little recognition that Earth’s orbit is a finite resource, the space and Earth environments are connected, and the actions of one actor can affect everyone.” Published: 20 May 2021 Boley, A.C., Byers, M. Satellite mega-constellations create risks in Low Earth Orbit, the atmosphere and on Earth. Sci Rep 11, 10642 (2021). https://doi.org/10.1038/s41598-021-89909-7 Photo by...
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Bio James C. Lin James C. Lin is a professor of bioengineering and electrical engineering at the University of Illinois Chicago. At the University of Illinois, Lin has served as head of the Bioengineering Department, Director of the Robotics and Automation Laboratory, and Director of Special Projects in the College of Engineering. He also held...
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Gutierrez Lopez DE, Lashinger LM, Weinstock GM, Bray MS. Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet. Cell Metab. 2021 May 4;33(5):873-887. doi: 10.1016/j.cmet.2021.03.015. Epub 2021 Mar 30. PMID: 33789092. Abstract The molecular circadian clock and symbiotic host-microbe relationships both evolved as mechanisms that enhance metabolic responses to environmental challenges....
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Sulli G, Manoogian ENC, Taub PR, Panda S. Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases. Trends in Pharmacological Sciences. 2018 Sep;39(9):812-827. DOI: 10.1016/j.tips.2018.07.003. Highlights Although circadian rhythm disruption (CRD) was typically considered to be a risk for chronic diseases solely for shift workers (∼20%...
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BACKGROUND INFORMATION Modern electric lighting enables people to work, sleep, eat, and receive services throughout the 24-hour day. As a result, many individuals encounter new patterns and types of electrical light, change the timing of their meals, and experience sleep disturbances and other stresses. Those factors can disrupt circadian rhythms and possibly lead to adverse...
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April 2021 Summary of NTP Cancer Hazard Conclusions Exposure Circumstances That Cause Circadian Disruption:Persistent Night Shift WorkCertain Lighting Conditions https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf Selected images: NTP Review of Shift Work at Night, Light at Night, and Circadian Disruption Topic Overview Status: NTP cancer hazard assessments Conclusion(s): NTP concluded that (1) persistent night shift work can cause breast cancer in women...
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Szkiela, M.; Kusideł, E.; Makowiec-Dąbrowska, T.; Kaleta, D. How the Intensity of Night Shift Work Affects Breast Cancer Risk. Int. J. Environ. Res. Public Health 2021, 18, 4570. https://doi.org/10.3390/ijerph18094570 Abstract Background—In 2019, the IARC concluded that “night shift work is probably carcinogenic to humans (Group 2A), based on limited evidence from human epidemiological studies and sufficient evidence of...
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Hatori M, Gronfier C, Van Gelder RN, et al. Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies. NPJ Aging and Mechanisms of Disease. 2017 ;3:9. DOI: 10.1038/s41514-017-0010-2. Abstract Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and...
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Russart KLG, Nelson RJ. Light at night as an environmental endocrine disruptor. Physiol Behav. 2018 Jun 1;190:82-89. doi: 10.1016/j.physbeh.2017.08.029. Epub 2017 Sep 7. PMID: 28870443; PMCID: PMC5839924. https://www.sciencedirect.com/science/article/abs/pii/S0031938417302743?via%3Dihub Abstract Environmental endocrine disruptors (EEDs) are often consequences of human activity; however, the effects of EEDs are not limited to humans. A primary focus over the past...
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Zhang, Z., Zeng, P., Gao, W. et al. Circadian clock: a regulator of the immunity in cancer. Cell Commun Signal 19, 37 (2021). https://doi.org/10.1186/s12964-021-00721-2 Abstract The circadian clock is an endogenous timekeeper system that controls and optimizes biological processes, which are consistent with a master circadian clock and peripheral clocks and are controlled by various genes. Notably, the disruption of...
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