Where the sun doesn’t shine? Skin UV exposure reflected in poop

October 24, 2019 , Frontiers

Excerpts:

The sun can indeed shine out of your backside, suggests research. Not because you’re self-absorbed, but because you’ve absorbed gut-altering UV radiation.

This is the first study to show that skin exposure to UVB light alters the gut  in humans. Published in Frontiers in Microbiology, the analysis suggests that  D mediates the change—which could help explain the protective effect of UVB light in  like MS and IBD.

Exposure to UVB in sunlight is well-known to drive vitamin D production in the skin, and recent studies suggest that vitamin D alters the . However, that UVB therefore causes gut microbiome changes, via vitamin D production, has so far been shown only in rodents.

In a new clinical pilot study, researchers tested the effect of skin UVB exposure on the human gut microbiome.

Healthy female volunteers (n=21) were given three one-minute sessions of full-body UVB exposure in a single week. Before and after treatment, stool samples were taken for analysis of gut bacteria—as well blood samples for vitamin D levels.

Skin UVB exposure significantly increased gut microbial diversity, but only in subjects who were not taking vitamin D supplements during the (winter) study (n=12).

Prior to UVB exposure, these women had a less diverse and balanced gut microbiome than those taking regular vitamin D supplements,” reports Prof. Bruce Vallance, who led the University of British Columbia study. “UVB exposure boosted the richness and evenness of their microbiome to levels indistinguishable from the supplemented group, whose microbiome was not significantly changed.”

The results also showed some agreement with mouse studies using UVB, such as an increase in Firmicutes and decrease in Bacteroidetes in the gut following exposure.

Prof. Bruce Vallance: “The results of this study have implications for people who are undergoing UVB phototherapy, and identifies a novel skin-gut axis that may contribute to the protective role of UVB light  in inflammatory diseases like MS and IBD.”

https://m.medicalxpress.com/news/2019-10-sun-doesnt-skin-uv-exposure.html?fbclid=IwAR29Sk681AauWIeZW_O7EifmFxBA8_KVwoaKBkD6GANRZ64_5cUEltsBJXg

More information: Frontiers in MicrobiologyDOI: 10.3389/fmicb.2019.02410 , https://www.frontiersin.org/articles/10.3389/fmicb.2019.02410/full

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