-
Alahmad YM, Aljaber M, Saleh AI, Yalcin HC, Aboulkassim T, Yasmeen A, Batist G, Moustafa AA. Effect of cell-phone radiofrequency on angiogenesis and cell invasion in human head and neck cancer cells. Head Neck. 2018 Oct;40(10):2166-2171. doi: 10.1002/hed.25210. Epub 2018 May 13. PMID: 29756334.
Abstract
Background
Today, the cell phone is the most widespread technology globally. However, the outcome of cell‐phone radiofrequency on head and neck cancer progression has not yet been explored.
Methods
The chorioallantoic membrane (CAM) and human head and neck cancer cell lines, FaDu and SCC25, were used to explore the outcome of cell‐phone radiofrequency on angiogenesis, cell invasion, and colony formation of head and neck cancer cells, respectively. Western blot analysis was used to investigate the impact of the cell phone on the regulation of E‐cadherin and Erk1/Erk2 genes.
Results
Our data revealed that cell‐phone radiofrequency promotes angiogenesis of the CAM. In addition, the cell phone enhances cell invasion and colony formation of human head and neck cancer cells; this is accompanied by a downregulation of E‐cadherin expression. More significantly, we found that the cell phone can activate Erk1/Erk2 in our experimental models.
Conclusion
Our investigation reveals that cell‐phone radiofrequency could enhance head and neck cancer by stimulating angiogenesis and cell invasion via Erk1/Erk2 activation.